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Genetic Variant is Major cause for Alcohol Flush Reaction and its Symptoms
Alcohol flush reaction is most often due to the genetic variant that affects one of the enzymes responsible for breaking down alcohol as described in the above four step process. This genetic variant is found in the ALDH2 gene. The ALDH2 gene regulates the production of the enzyme Aldehyde Dehydrogenase 2 which is responsible for transforming Acetaldehyde into acetic acid. The ALDH2*2 allele is dominant. This means that even one copy of it interferes with the formation of a fully functional ALDH2 enzyme, with the result that Acetaldehyde cannot be broken down and builds up in the body when drinking alcohol, leading to the symptoms described above. The ALDH2*2 variant is most common with Asians.
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